Types of laryngeal cancer

The type of laryngeal cancer means the type of cell the cancer started in. The most common type is squamous cell carcinoma (SCC).

Squamous cell cancer (carcinoma) of the larynx

Most laryngeal cancers are squamous cell carcinoma. Carcinoma means cancer. So squamous cell carcinoma is cancer that starts in these cells.

The cancer develops in the flat, skin like, squamous cells that cover the surface of the vocal cords and other parts of the larynx.

Cancers that start in gland cells (adenocarcinoma)

Adenocarcinoma is uncommon compared to squamous cell laryngeal cancer. It starts in the adenomatous cells that are around the surface of the larynx. Adenomatous cells are gland cells that produce mucus Open a glossary item.

Other types of cancer found in the larynx

Rarely, other types of cancer occur in the larynx. The treatment for these is different to the treatment described in this section.

Sarcoma of the larynx

Sarcomas of the larynx are extremely rare. Sarcomas are cancers that start in the body’s connective tissues.

Connective tissues are the supporting tissues of the body, such as bone, muscle, and nerves. Cartilage is the supporting tissue of the larynx. Cancers that develop from cartilage are called chondrosarcomas.

Lymphoma of the larynx

Lymphoma is a cancer of the lymphatic system Open a glossary item. It starts in the lymph glands Open a glossary item or other organs of the lymphatic system. There are many lymph nodes in the neck. Swelling of a lymph node is a symptom of lymphoma. It is possible to get lymphoma in the larynx, but this is rare.

If you are looking for information on lymphoma, visit the lymphoma section. Your treatment will be different to the treatment outlined in this section for laryngeal cancer.

Plasmacytoma in the larynx

Plasmacytoma in the larynx is rare. It can progress into a type of cancer called myeloma. Myeloma is a type of blood cancer.

Non cancerous changes in the voice box

Many diseases of the larynx are not cancer. Here are some conditions that affect the larynx that are not cancerous.

Chronic laryngitis

Chronic laryngitis or swelling of the voice box lining is usually caused by:

  • smoking – the larynx is irritated by the smoke, resulting in inflammation
  • acid reflux – acid from the stomach leaks up into the food pipe (oesophagus)
  • postnasal drip – mucus from the back of the nose running down the throat
  • straining the voice – this can occur in people who use their voices a lot, for example, singers, teachers and sports coaches

Your doctor can tell you how to deal with chronic laryngitis. You may need a biopsy if your doctor wants to rule out any risk of your laryngitis being caused by a cancer.

Laryngeal nodules

Nodules are overgrowths of tissue on the vocal cords. They may be caused by smoking, acid reflux and straining the voice. They are a common cause of hoarseness. The treatment you have for nodules will depend on:

  • what caused them
  • the size of the nodules
  • what problems they are causing

Resting your voice can sometimes help. Treatment might include:

  • surgery if they are large
  • speech therapy

Papillomas

The human papillomavirus (HPV) can cause wart like growths on your larynx. These aren’t cancer, they are papillomas or papillary growths. Papillomas can become laryngeal cancer, but this is very rare.

Treatment for laryngeal cancer

The treatment you have depends on several things including:

  • where exactly the cancer is
  • how big the cancer is
  • whether the cancer has spread to other parts of the body
  • BMJ Best Practice

    M Pierce

    Last reviewed: 24 Apr 2024 Last updated: 16 Apr 2024 (accessed July 2024)

  • Ross and Wilson Anatomy and Physiology in Health and Illness (14th edition)    
    A Waugh and A Grant
    Elsevier Ltd, 2023

  • Laryngeal soft tissue sarcoma: Systematic review and individual patient data analysis of 300 cases

    A V Ramdulari and others.

    Head & Neck, 2021. Volume 43, Issue 5

  • Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS- ESMO -ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up

    J P Machiels and others

    Annals of Oncology, 2020. Volume 31, Issue 11

Last reviewed: 
22 Jul 2024
Next review due: 
22 Jul 2027

Related links