Risks and causes of chronic lymphocytic leukaemia (CLL)

Chronic lymphocytic leukaemia (CLL) is not clearly linked to any preventable causes. We don’t know what causes CLL but there are some risk factors Open a glossary item that can increase your risk of developing it. These are:

  • being older
  • being male
  • having a family history of CLL

What is a risk factor?

Anything that can increase your risk of getting a disease is called a risk factor.

Different cancers have different risk factors.­ Having one or more of these risk factors doesn't mean you will definitely get that cancer.

Risk factors for CLL include:

Age

Your risk of developing CLL increases as you get older. It is very rare in people younger than 40.

Sex

Men are more likely to develop CLL than women. We don't know why that is.

Family history

We know that there is some kind of inherited Open a glossary item genetic change in some people with CLL. But most people with CLL do not have a family history of it. 

You have a higher risk of developing CLL if a close family member (parent, sibling, child) has CLL. But most people with a family history of CLL do not develop it themselves.

Where there isn't clear evidence

Some factors might increase the risk of CLL but there is not enough evidence to be sure.

Exposure to chemicals

Some studies suggest that certain hair dyes might increase the risk of developing CLL. But we need more research to clarify if hair dye use today increases the risk of CLL.

Living on a farm,or being exposed to herbicides and pesticides may be linked to an increased risk of CLL.

Other possible causes

There are often stories about potential causes in the media. It isn’t always clear which ideas are supported by evidence. There might be things you have heard of that we haven’t included here. This is because either there is no evidence about them or it is less clear.

Reducing your risk

There are ways you can reduce your risk of cancer.

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    B Eichorst and others.
    Annals of Oncology, 2021. Volume 32, Issue 1, pages 22-33

  • Personal use of hair dyes and risk of leukemia: a systematic literature review and meta‐analysis
    K Towle and others
    Cancer Medicine, 2017. Volume 6, Issue 10, pages 2471–2486

  • Medical History, Lifestyle, Family History, and Occupational Risk Factors for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
    S Slager and others
    Journal of National Cancer Institute Monographs, 2014. Volume 48, pages 41–51

  • Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk

    A Sud and others

    Blood, 2019. Volume 134, Issue 2, pages 960-969

  • The fraction of cancer attributable to known risk factors in England, Wales, Scotland, Northern Ireland, and the UK overall in 2015
    KF Brown and others
    British Journal of Cancer, 2018. Volume 118, Issue 8, pages 1130 to 1141

  • List of classifications by cancer sites with sufficient or limited evidence in humans, IARC Monographs Volumes 1–136a

    The Internal Agency for Research on Cancer (IARC), last updated July 2024

    Accessed August 2024

  • The information on this page is based on literature searches and specialist checking. We used many references and there are too many to list here. If you need additional references for this information please contact patientinformation@cancer.org.uk with details of the particular issue you are interested in.

Last reviewed: 
30 Aug 2024
Next review due: 
30 Aug 2027

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